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Introduction: In several fields, the process of fusing multiple two-dimensional
(2D) closed lines is an important step. For instance, this is fundamental in histology
and oncology in general. The treatment of a tumor consists of numerous steps
and activities. Among them, segmenting the cancer area, that is, the correct
identification of its spatial location by the segmentation technique, is one of the
most important and at the same time complex and delicate steps. The difficulty in
deriving reliable segmentations stems from the lack of a standard for identifying
the edges and surrounding tissues of the tumor area. For this reason, the entire
process is affected by considerable subjectivity. Given a tumor image, different
practitioners can associate different segmentations with it, and the diagnoses
produced may differ. Moreover, experimental data show that the analysis of the
same area by the same physician at two separate timepoints may result in
different lines being produced. Accordingly, it is challenging to establish which
contour line is the ground truth