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3차원 세포배양 플랫폼 항암제 감수성 및 효능/독성 검사 전문 기업

3차원 세포배양 플랫폼 항암제 감수성 및 효능/독성 검사
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논문 2021, Marine drugs, Inhibition of SARS‐CoV‐2 Virus Entry by the Crude…

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작성자 MBD
댓글 0건 조회 48회 작성일 21-04-23 10:28

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Abstract:
Much attention is being devoted to the potential of marine sulfated polysaccharides as
antiviral agents in preventing COVID‐19. In this study, sulfated fucoidan and crude polysaccha‐
rides, extracted from six seaweed species (Undaria pinnatifida sporophyll, Laminaria japonica,
Hizikia fusiforme, Sargassum horneri, Codium fragile, Porphyra tenera) and Haliotis discus hannai
(abalone viscera), were screened for their inhibitory activity against SARS‐CoV‐2 virus entry. Most
of them showed significant antiviral activities at an IC50 of 12~289  μg/mL against SARS‐CoV‐2
pseudovirus in HEK293/ACE2, except for P. tenera (IC50 > 1000 μg/mL). The crude polysaccharide
of S. horneri showed the strongest antiviral activity, with an IC50 of 12 μg/mL, to prevent COVID‐
19 entry, and abalone viscera and H. fusiforme could also inhibit SARS‐CoV‐2 infection with an
IC50 of 33 μg/mL and 47 μg/mL, respectively. The common properties of these crude polysaccha‐
rides, which have strong antiviral activity, are high molecular weight (>800 kDa), high total carbo‐
hydrate (62.7~99.1%), high fucose content (37.3~66.2%), and highly branched polysaccharides.
These results indicated that the crude polysaccharides from seaweeds and abalone viscera can ef‐
fectively inhibit SARS‐CoV‐2 entry